Table 3.
The CVDs target information.
| Gene name | Protein name | Degree |
|---|---|---|
| ESR1 | Estrogen receptor | 15 |
| ESR2 | Estrogen receptor beta | 14 |
| PIM1 | Proto-oncogene serine/threonine-protein kinase Pim-1 | 14 |
| AR | Androgen receptor | 13 |
| HSP90AA1 | Heat shock protein HSP 90-alpha | 12 |
| MAPK14 | Mitogen-activated protein kinase 14 | 12 |
| NOS2 | Nitric oxide synthase, inducible | 12 |
| PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 12 |
| PPARG | Peroxisome proliferator-activated receptor gamma | 12 |
| PTGS1 | Prostaglandin G/H synthase 1 | 12 |
| PTGS2 | Prostaglandin G/H synthase 2 | 12 |
| PTPN1 | Tyrosine-protein phosphatase non-receptor type 1 | 12 |
| CDK2 | Cell division protein kinase 2 | 11 |
| GSK3B | Glycogen synthase kinase-3 beta | 11 |
| ALOX12 | Arachidonate 12-lipoxygenase, 12S-type | 10 |
| CCNA2 | Cyclin-A2 | 10 |
| ALOX5 | Arachidonate 5-lipoxygenase | 9 |
| CA2 | Carbonic anhydrase 2 | 9 |
| MAOA | Amine oxidase [flavin-containing] A | 9 |
| NCOA2 | Nuclear receptor coactivator 2 | 9 |
| CSNK2A1 | Casein kinase II subunit alpha | 7 |
| CSNK2B | Casein kinase II subunit beta | 7 |
| CYP19A1 | Cytochrome P450 19A1 | 7 |
| DPP4 | Dipeptidyl peptidase 4 | 7 |
| HSD17B3 | Estradiol 17-beta-dehydrogenase 3 | 7 |
| PIK3CA | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 7 |
| CHEK1 | Serine/threonine-protein kinase Chk1 | 6 |
| MAOB | Amine oxidase [flavin-containing] B | 6 |
| CASP3 | Caspase-3 | 5 |
| IMPA2 | Inositol monophosphatase 2 | 5 |
| MIF | Macrophage migration inhibitory factor | 5 |
| PRSS1 | Trypsin-1 | 5 |
| BAX | Apoptosis regulator BAX | 4 |
| GLO1 | Lactoylglutathione lyase | 4 |
| IMPA1 | Inositol monophosphatase | 4 |
| TOP2A | DNA topoisomerase 2-alpha | 4 |
| VCAM1 | Vascular cell adhesion protein 1 | 4 |
| AKR1B1 | Aldose reductase | 3 |
| CAT | Catalase | 3 |