Fig. 1.

Domain architecture of BS69 protein and its interaction partners. Diagram of the full-length BS69 protein with the various reader domains and the C-terminal MYND domain highlighted in different colors and with their amino acid positions indicated. BROMO and PWWP domains are responsible for H3.3K36me3 recognition (23, 24) whereas the EFTUD2 binding site is located at amino acids 556–562 (24). The other BS69-interacting proteins are grouped into different categories. Interacting proteins reported previously are in brown, and the proteins present in the FLAG-HA-BS69 immunoprecipitate, identified by mass spectrometry reported in the Guo et al. study (24), are in black.