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. 2015 Jun 9;9:149. doi: 10.3389/fnbeh.2015.00149

Figure 1.

Figure 1

Wiring diagram of the optic lobes of wild type and the Dscam2 mutant. Schematic of wild type (WT) (left-side) and Dscam2 mutant (right-side) optic lobes with wiring details highlighted in boxes. Photoreceptors R1-6 (brown) in the retina form synapses with a postsynaptic complex that includes L1 (green) and L2 (blue) lamina neurons. Photoreceptors R7 (red) and R8 (not-shown) project directly to the medulla. (1) In WT animals, L1 and L2 are postsynaptic at every photoreceptor synapse. (2) In Dscam2 mutant animals, 40% of the photoreceptor synapses within fused cartridges contain two L2 elements, one of which is from a neighboring cartridge. (3) L2 dendritic arbors project into neighboring lamina cartridges when they lack Dscam2. (4) Dscam2 restricts L1 lamina neuron axons to a single column in the medulla. (5) R7 and R8 axons are disorganized in Dscam2 mutant animals frequently crossing over into adjacent medulla columns; this phenotype is non-autonomous.