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. 2015 Jun 9;9:214. doi: 10.3389/fncel.2015.00214

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Copyright © 2015 Bing, Wu, Chu and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LTD of GABAergic transmission at PCs was induced by a CB1 receptor agonist. (A) Representative cell-attached recording traces showing air-puff stimulation (10 ms, 60 psi)-evoked responses in a cerebellar PC before (left) and after application of CB1 agonist WIN55212-2 (5 μM; 10 min). (B) Time course of normalized amplitude of P1 (shown in A) before and after application of CB1 agonist WIN55212-2 (5 μM; 10 min; shadow). (C) Pooled data showing the average normalized amplitude of P1 before and after application of CB1 agonist WIN55212-2 (5 μM; 10 min; shadow; n = 7). Note that application of CB1 agonist WIN55212-2 for 10 min induced LTD of P1. Data points are mean ± SEM.