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. 2015 May 26;16(Suppl 5):S3. doi: 10.1186/1471-2164-16-S5-S3

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Copyright © 2015 Aibar et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Gene network obtained for AML with the RNA-seq dataset. The network contains the top-30 ranked genes selected after running geNetClasifier to analyse the RNA-Seq expression data of normal karyoptype AML (nk-AML) versus AML with t(15;17) (APL) samples. The network shows two clear clusters: one including genes that are up-regulated in nk-AML and another with down-regulated genes. The red cluster includes many homeobox (HOX) genes highly correlated. These genes are characteristic of nk-AMLs and show good agreement with the results obtained with microarrays in spite of being two totally independent datasets.