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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Semin Radiat Oncol. 2015 Feb 21;25(3):172–180. doi: 10.1016/j.semradonc.2015.02.003

Figure 2.

Figure 2

The patient was a 43 yo male with grade 2 gemistocytic astrocytoma of the right temporal lobe treated on a clinical protocol with definitive radiation to 59.4 Gy and adjuvant temozolomide who remained without disease progression at last follow-up. Top panel shows pre-RT T2/FLAIR MRI (left) and overlying radiation dose distribution (right). Middle panel shows fractional anisotropy (FA) maps, a measure of anisotropic diffusion that reflects overall white matter fiber integrity, pre-RT (left) and 18 months post-RT (right). Bottom panel shows an enlarged view of the area within the white boxes; right and left cingulum outlined in white. FA declined by 30% in the right cingulum, and by 1% in the left. The patient experienced a significant decline of 5 standard deviations in delayed recall at 18 months compared to pre-RT.