Table 2.
Drug-mental disorders associations (weight ≥ 0.5)
| ID | Drug ID | Drug Name | Weight | ID | Drug ID | Drug Name | Weight |
|---|---|---|---|---|---|---|---|
| 1 | DB00904 | Ondansetron | 0.89 | 27 | DB00334 | Olanzapine | 0.82 |
| 2 | DB00669 | Sumatriptan | 0.85 | 28 | DB01186 | Pergolide | 0.82 |
| 3 | DB00734 | Risperidone | 0.73 | 29 | DB01618 | Molindone | 0.82 |
| 4 | DB00490 | Buspirone | 0.77 | 30 | DB06684 | Vilazodone | 0.82 |
| 5 | DB01149 | Nefazodone | 0.93 | 31 | DB01621 | Pipotiazine | 0.82 |
| 6 | DB01142 | Doxepin | 0.83 | 32 | DB01616 | Alverine | 0.82 |
| 7 | DB01392 | Yohimbine | 0.87 | 33 | DB01200 | Bromocriptine | 0.82 |
| 8 | DB00540 | Nortriptyline | 0.89 | 34 | DB00216 | Eletriptan | 0.81 |
| 9 | DB01224 | Quetiapine | 0.82 | 35 | DB01622 | Thioproperazine | 0.79 |
| 10 | DB00363 | Clozapine | 0.82 | 36 | DB01614 | Acepromazine | 0.79 |
| 11 | DB00477 | Chlorpromazine | 0.78 | 37 | DB00960 | Pindolol | 0.77 |
| 12 | DB00571 | Propranolol | 0.75 | 38 | DB04946 | Iloperidone | 0.76 |
| 13 | DB00321 | Amitriptyline | 0.69 | 39 | DB08807 | Bopindolol | 0.75 |
| 14 | DB00726 | Trimipramine | 0.90 | 40 | DB08815 | Lurasidone | 0.75 |
| 15 | DB00247 | Methysergide | 0.87 | 41 | DB06216 | Asenapine | 0.74 |
| 16 | DB00656 | Trazodone | 0.86 | 42 | DB01049 | Ergoloid mesylate | 0.74 |
| 17 | DB00315 | Zolmitriptan | 0.85 | 43 | DB05271 | Rotigotine | 0.72 |
| 18 | DB00952 | Naratriptan | 0.85 | 44 | DB01267 | Paliperidone | 0.72 |
| 19 | DB08810 | Cinitapride | 0.84 | 45 | DB01359 | Penbutolol | 0.60 |
| 20 | DB00589 | Lisuride | 0.84 | 46 | DB00866 | Alprenolol | 0.60 |
| 21 | DB00268 | Ropinirole | 0.84 | 47 | DB00696 | Ergotamine | 0.56 |
| 22 | DB00413 | Pramipexole | 0.84 | 48 | DB00998 | Frovatriptan | 0.55 |
| 23 | DB00714 | Apomorphine | 0.83 | 49 | DB00918 | Almotriptan | 0.55 |
| 24 | DB00248 | Cabergoline | 0.83 | 50 | DB00953 | Rizatriptan | 0.53 |
| 25 | DB01238 | aripiprazole | 0.82 | 51 | DB00320 | Dihydroergotamine | 0.50 |
| 26 | DB00246 | ziprasidone | 0.82 | ||||
Drug ID represents the unique DrugBank accession number of a drug. Drug Name represents the corresponding name of a Drug ID. Weight represents the correlation between a drug and the mental disorder. 40 drugs are approved by our benchmark, 9 predicted drugs are supported by literature (in bold italic), and 2 are not directly supported by the literatures (in underlined bold).