Table 3.
Drug-hypertension associations (weight ≥ 0.5)
| ID | Drug ID | Drug Name | Weight | ID | Drug ID | Drug Name | Weight |
|---|---|---|---|---|---|---|---|
| 1 | DB06216 | Asenapine | 0.71 | 17 | DB00413 | Pramipexole | 0.52 |
| 2 | DB00571 | Propranolol | 0.66 | 18 | DB00589 | Lisuride | 0.52 |
| 3 | DB08807 | Bopindolol | 0.66 | 19 | DB01149 | Nefazodone | 0.52 |
| 4 | DB00960 | Pindolol | 0.64 | 20 | DB00247 | Methysergide | 0.52 |
| 5 | DB00866 | Alprenolol | 0.59 | 21 | DB01049 | Ergoloid mesylate | 0.52 |
| 6 | DB01359 | Penbutolol | 0.59 | 22 | DB00714 | Apomorphine | 0.52 |
| 7 | DB01200 | Bromocriptine | 0.54 | 23 | DB00656 | Trazodone | 0.51 |
| 8 | DB00248 | Cabergoline | 0.54 | 24 | DB01142 | Doxepin | 0.50 |
| 9 | DB00246 | Ziprasidone | 0.53 | 25 | DB00904 | Ondansetron | 0.50 |
| 10 | DB00334 | Olanzapine | 0.53 | 26 | DB08815 | Lurasidone | 0.50 |
| 11 | DB01238 | Aripiprazole | 0.53 | 27 | DB00216 | Eletriptan | 0.50 |
| 12 | DB00363 | Clozapine | 0.53 | 28 | DB00734 | Risperidone | 0.50 |
| 13 | DB01224 | Quetiapine | 0.53 | 29 | DB00726 | Trimipramine | 0.50 |
| 14 | DB01186 | Pergolide | 0.53 | 30 | DB04946 | Iloperidone | 0.50 |
| 15 | DB01392 | Yohimbine | 0.52 | 31 | DB01267 | Paliperidone | 0.50 |
| 16 | DB00268 | Ropinirole | 0.52 | ||||
Drug ID represents the unique DrugBank accession number of a drug. Drug Name represents the corresponding name of a Drug ID. Weight represents the value of correlation between a drug and the mental disorders. 26 drugs are approved by our benchmark. Among the remaining 5 drugs, 4 (in bold italic) have negative relationships with the mental disorders and 1 (in underlined bold) has a positive relationship with the mental disorders.