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. 2015 May 27;2015(5):CD001914. doi: 10.1002/14651858.CD001914.pub2

Comparison 1. Oral protein calorie supplements compared with no intervention, placebo or additional nutritional advice.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Change in weight in kg 3   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.1 3 months 2 107 Mean Difference (IV, Fixed, 95% CI) 0.24 [‐0.18, 0.66]
1.2 6 months 3 125 Mean Difference (IV, Fixed, 95% CI) 0.42 [‐0.12, 0.96]
1.3 12 months 1 102 Mean Difference (IV, Fixed, 95% CI) 0.16 [‐0.68, 1.00]
2 Change in weight Z score 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
2.1 3 months 2 107 Mean Difference (IV, Fixed, 95% CI) ‐0.02 [‐0.15, 0.11]
2.2 6 months 2 109 Mean Difference (IV, Fixed, 95% CI) 0.03 [‐0.10, 0.16]
2.3 12 months 1 102 Mean Difference (IV, Fixed, 95% CI) 0.08 [‐0.06, 0.22]
3 Change in height in cm 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
3.1 3 months 2 107 Mean Difference (IV, Fixed, 95% CI) ‐0.39 [‐1.15, 0.38]
3.2 6 months 2 109 Mean Difference (IV, Fixed, 95% CI) ‐0.40 [‐1.23, 0.42]
3.3 12 months 1 102 Mean Difference (IV, Fixed, 95% CI) 0.05 [‐0.67, 0.77]
4 Change in height Z score 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
4.1 3 months 2 107 Mean Difference (IV, Fixed, 95% CI) ‐0.09 [‐0.25, 0.08]
4.2 6 months 2 109 Mean Difference (IV, Fixed, 95% CI) ‐0.10 [‐0.26, 0.07]
4.3 12 months 1 102 Mean Difference (IV, Fixed, 95% CI) 0.02 [‐0.07, 0.11]
5 Change in body mass index 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
5.1 3 months 2 107 Mean Difference (IV, Fixed, 95% CI) 0.15 [‐0.08, 0.38]
5.2 6 months 2 109 Mean Difference (IV, Fixed, 95% CI) 0.18 [‐0.12, 0.47]
5.3 12 months 1 102 Mean Difference (IV, Fixed, 95% CI) 0.08 [‐0.28, 0.44]
6 Change in body mass index Z score 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
6.1 3 months 2 107 Mean Difference (IV, Fixed, 95% CI) 0.07 [‐0.08, 0.23]
6.2 6 months 2 10 Mean Difference (IV, Fixed, 95% CI) ‐0.46 [‐1.18, 0.26]
6.3 12 months 1 102 Mean Difference (IV, Fixed, 95% CI) 0.08 [‐0.12, 0.28]
7 Change in % ideal weight for height 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
7.1 3 months 1 8 Mean Difference (IV, Fixed, 95% CI) ‐2.75 [‐9.55, 4.05]
7.2 6 months 1 8 Mean Difference (IV, Fixed, 95% CI) ‐5.5 [‐12.73, 1.73]
8 Change in mid‐arm muscle circumference 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
8.1 3 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.2 6 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.3 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
9 Change in total energy intake (kcal/day) 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
9.1 1 month 1 8 Mean Difference (IV, Fixed, 95% CI) 70.5 [‐249.69, 390.69]
9.2 3 months 2 53 Mean Difference (IV, Fixed, 95% CI) 133.43 [‐102.94, 369.79]
9.3 6 months 1 48 Mean Difference (IV, Fixed, 95% CI) 304.86 [5.62, 604.10]
9.4 12 months 1 58 Mean Difference (IV, Fixed, 95% CI) 265.70 [42.94, 488.46]
10 Change in total fat intake (g/day) 2   Mean Difference (IV, Random, 95% CI) Subtotals only
10.1 1 month 1 8 Mean Difference (IV, Random, 95% CI) 15.48 [‐12.58, 43.54]
10.2 3 months 2 53 Mean Difference (IV, Random, 95% CI) 27.31 [‐42.72, 97.33]
10.3 6 months 1 48 Mean Difference (IV, Random, 95% CI) 11.71 [‐2.99, 26.41]
10.4 12 months 1 58 Mean Difference (IV, Random, 95% CI) 8.85 [‐4.64, 22.34]
11 Change in total protein intake (g/day) 2   Mean Difference (IV, Fixed, 95% CI) Subtotals only
11.1 1 month 1 8 Mean Difference (IV, Fixed, 95% CI) 4.15 [‐24.62, 32.92]
11.2 3 months 2 53 Mean Difference (IV, Fixed, 95% CI) 3.45 [‐5.87, 12.76]
11.3 6 months 1 48 Mean Difference (IV, Fixed, 95% CI) 8.77 [‐1.24, 18.78]
11.4 12 months 1 58 Mean Difference (IV, Fixed, 95% CI) 6.82 [‐2.36, 16.00]
12 Disease severity score 2   Mean Difference (IV, Fixed, 95% CI) Totals not selected
12.1 FEV1 % predicted at 3 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
12.2 Change in FEV1 % predicted at 3 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
12.3 Change in FEV1 % predicted at 6 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
12.4 Change in FEV1 % predicted at 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
12.5 Change in FVC % predicted at 3 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
12.6 Change in FVC % predicted at 6 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
12.7 Change in FVC % predicted at 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
13 Gastro‐intestinal symptom score 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
13.1 12 months 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
14 Headache 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
14.1 3 months 1   Peto Odds Ratio (Peto, Fixed, 95% CI) 0.0 [0.0, 0.0]