Date	Event	Description
20 May 2015	New citation required but conclusions have not changed	A new review team has taken on this review at the 2015 update. Despite the inclusion of one new trial (in a different disease area than those trials previously included), the conclusions of the review have not changed.
20 May 2015	New search has been performed	Three new studies were identified in the latest searches; one of these has been included in the updated review (Bayram 2009) and one has been excluded with reasons (Botrán 2011). The third new study is still ongoing and the authors have been contacted to ascertain when the published data will be available (Cox 2014). One reference that was previously listed as 'Awaiting classification' has now been included under the main (already included) study ID with confirmation of the paediatric data from the authors (Kalnins 1996). Five further studies that were previously listed as 'Awaiting classification' have now been excluded (Jain 2006; Johnson 2006; Nielson 2007; Powers 2006; Rollins 2007). One study that was previously listed as 'Awaiting classification' has been identified as part of an already excluded study (Rickard 1989).
12 August 2009	Amended	Contact details updated.
10 November 2008	New search has been performed	17 new trials were identified in the latest searches: 12 new trials have been listed as excluded (Abdulhamid 2008; Bruzzese 2007; Lloyd‐Still 2006; Manguso 2005; Marques 2004; Ndekha 2005; Newby 2007; Oudshoorn 2007; Papas 2007; Soliman 2004; Stark 2005; Teixido‐Planas 2005); five new trials have been listed as 'Awaiting classification' (Jain 2006a; Johnson 2006a; Nielson 2007a; Powers 2006a; Rollins 2007a). One trial which was previously listed as ongoing has now been published in full and has been included in the review (Poustie 2006); one additional reference to an already included trial has also been listed as 'Awaiting classification' until we are able to obtain and analyse data for paediatric participants only (Kalnins 2005). We have obtained the published paper from one trial which was previously listed as 'Awaiting classifcation' and we have now judged this to be not eligible to be listed even as an excluded study.
10 April 2008	Amended	Converted to new review format.
14 November 2005	New search has been performed	A search was run in November 2004 and no new references were found which were eligible for inclusion in the review.
27 January 2004	New search has been performed	A search was run in August 2003 and identified 13 new references. Not all of these were eligible for inclusion in the review, but two of the references (Lepage 2002; Pelekanos 1990) have been added to 'Excluded studies'.
16 October 2002	New search has been performed	An update of the review was completed in October 2002. No additional studies were found to be eligible for inclusion in the review.
21 May 1999	New citation required and conclusions have changed	Substantive amendment