| Study | Reason for exclusion |
|---|---|
| Abdulhamid 2008 | Intervention is zinc supplements, not an oral calorie supplement. |
| Agtmaal 1990 | Not children with chronic disease / not OPCS. |
| Akobeng 2000 | Not OPCS. |
| Akobeng 2007 | Not OPCS. |
| Alexander 1980 | Not children with chronic disease / not OPCS. |
| Arora 1998 | Not children with chronic disease / not OPCS. |
| Attard‐Montalto 1998 | Not OPCS. |
| Badaloo 1999 | Not OPCS. |
| Ball 1989 | Not OPCS. |
| Barbosa 1999 | Not OPCS. |
| Bengoa 1985 | Not children with chronic disease. |
| Bennett 1999 | Not OPCS. |
| Bernstein 1999 | Not OPCS. |
| Berry 1975 | Not RCT. |
| Borrelli 2006 | Not OPCS |
| Botrán 2011 | Interevntion duration less than one month |
| Braga 1999 | Adult study. |
| Bruzzese 2007 | Not OPCS. |
| Cassidy 1999 | Not OPCS. |
| Chan 1990 | Not OPCS. |
| Chawla 1983 | Not children with chronic disease / not OPCS / unclear if RCT. |
| Coghlin‐Dickson 2000 | Not OPCS. |
| Dartois 1995 | Not OPCS. |
| Dhanraj 1997 | Not children with chronic disease / not OPCS. |
| Dykman 1998 | Not children with chronic disease / not OPCS. |
| Dziechciarz 2007 | Not RCT |
| Edefonti 1999 | Not RCT / not OPCS. |
| Elhasid 1999 | Not RCT. |
| English 1997 | Not children with chronic disease / not OPCS. |
| Fauveau 1992 | Not children with chronic disease. |
| Fell 2000 | Not RCT. |
| Gianotti 1999 | Not children with chronic disease / not OPCS. |
| Gibson 1998 | Not OPCS. |
| Gottrand 1999 | Not OPCS. |
| Granados 1998 | Not OPCS. |
| Haffejee 1980 | Not OPCS. |
| Hanafy 1967 | Not RCT. |
| Hansen 1996 | Not children with chronic disease / not OPCS. |
| Heikens 1989 | Not children with chronic disease. |
| Hopman 1997 | Not children with chronic disease. |
| Hopman 1998 | Not OPCS. |
| INCAP Study | Not children with chronic disease / not OPCS. |
| Iyengar 1979 | Not children with chronic disease. |
| Jackson 1990 | Not children with chronic disease. |
| Jain 2006 | Not OPCS |
| Jamaican Study 1996 | Not children with chronic disease. |
| Johnson 2006 | Both groups received supplemental amino acids |
| Kabir 1994 | Not children with chronic disease / not OPCS. |
| Karkos 2007 | Not RCT |
| Kashirskaja 1996 | Not RCT / not OPCS. |
| Kaur 1979 | Not children with chronic disease / not OPCS. |
| Keele 1995 | Adult study. |
| Kendell 1982 | Adult study / not OPCS. |
| Kingston Project '93 | Not children with chronic disease. |
| Knops 1999 | Not RCT. |
| Kobayashi 1998 | Not OPCS. |
| Koletzko 1992 | Quasi‐randomised study where treatment & comparison group not comparable. |
| Koretz 2007 | Not RCT |
| Kossmann 2000 | Not children with chronic disease / not OPCS. |
| Ladas 2006 | Not RCT |
| Lagstrom 1999 | Not children with chronic disease / not OPCS. |
| Lambert 1995 | Not OPCS. |
| Lepage 2002 | Not OPCS. |
| Linday 2004 | Not OPCS |
| Lloyd‐Still 2006 | Not OPCS. |
| Lutter 2008 | Not RCT |
| Maes 1997 | Not RCT. |
| Mahlungulu 2007 | Not RCT. |
| Manguso 2005 | Not children with chronic disease/Not OPCS. |
| Marques 2004 | Not RCT / Not OPCS. |
| Martorell 1995 | Not children with chronic disease. |
| Mathisen 1999 | Not RCT. |
| McCargar 1998 | Not children with chronic disease / Not OPCS. |
| McClure 2000 | Not OPCS. |
| McWhirter 1994 | Adult study / OPCS administered for less than 1 month. |
| Mok 2006 | Not OPCS |
| Mora 1981 | Not children with chronic disease. |
| Ndekha 2005 | Not OPCS. |
| Newby 2007 | Not RCT ‐ review article. |
| Nielson 2007 | The median age of the sample was 36 and 35 years in both groups. lowest age range in one group was 15 years but data was not presented disaggregated according to age. |
| Oudshoorn 2007 | Intervention uses micronutrient supplements not oral calorie supplements. |
| Papadopoulou 1998 | Not RCT ‐ review article. |
| Papas 2007 | Pharmacokinetic trial of different formulations of vitamin E supplementation, not oral calorie supplementation. |
| Pelekanos 1990 | Not OPCS. |
| Powers 1999 | Not OPCS. |
| Powers 2006 | Not OPCS. |
| Raynor 1999 | Not OPCS. |
| Reifsnider 1998 | Not children with chronic disease / not OPCS. |
| Rettammel 1995 | Not RCT. |
| Rickard 1983 | Not OPCS. |
| Rickard 1984 | Not OPCS. |
| Rickard 1989 | Not OPCS. |
| Rock 1999 | Not OPCS. |
| Rollins 2007 | Oral protein supplement intervention arm only provided to children under 1 year of age. |
| Saiyed 2000 | Not children with chronic disease / not OPCS. |
| Shaw 1999 | Not OPCS. |
| Shepherd 1988 | Not OPCS. |
| Sirisinha 1973 | Not OPCS. |
| Soliman 2004 | Not RCT/Not OPCS |
| Sondel 1987 | Intervention for less than 1 month. |
| Stark 2005 | Not OPCS. |
| Taylor 1999 | Not children with chronic disease / not OPCS. |
| Teixido‐Planas 2005 | Not children with chronic disease. |
| van Eys 1982 | Not OPCS. |
| Walker 2000 | Not children with chronic disease / not OPCS. |
| Yamamoto 2007 | Not RCT |
OPCS: oral protein calorie supplements RCT : randomised controlled trial