Comparison 2. Home observed versus clinic observed.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Cure (having a negative sputum smear test in the last month of treatment having been smear‐positive initially)	4	1556	Risk Ratio (M‐H, Random, 95% CI)	1.02 [0.88, 1.18]
2 Treatment completion (both with smear sputum test at end and those without)	3	1034	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.91, 1.17]
3 Cure (stratified by intensity of observation)	4	1556	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.91, 1.11]
3.1 DOT (Intense supervision of observer)	1	522	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.91, 1.28]
3.2 Routine supervision of DOT	3	1034	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.86, 1.10]