Fig. 7.

Potential mechanisms by which Emc promotes Notch-induced growth. Da has been shown to regulate G1/S via modulation of dacapo and string expression levels. Our data indicate that Emc-mediated sequestration of Da is required to promote growth in the eye. We also have evidence that Emc regulates expression levels of Myc, another regulator of the G1/S checkpoint. The model summarizes current data and proposes that Notch activation of emc leads to the sequestration of Da by Emc and the activation of Myc. These events ultimately result in the passage of the cell through the G1/S checkpoint.