Table 1.
Coexpressed gene sets shared by more than 7 brain diseases.
| Brain diseases sharing gene sets | Avg. PCC | Diff significance* | Genes | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AD | ALS | HD | MS | PD | SCH | BD | AUT | Brain disease | Normal | P-value | Benjamini | |
| 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0.908 | 0.509 | 1.30E-03 | 4.804E-03 | AKR1D1, FKTN |
| 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0.854 | 0.084 | 4.00E-05 | 8.759E-04 | LUC7L2, SULT1A1 |
| 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0.884 | 0.343 | 4.20E-04 | 2.791E-03 | ARHGEF3, ATP1A1 |
| 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0.711 | 0.184 | 4.70E-04 | 2.977E-03 | CROCC, PDE9A |
| 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0.879 | 0.431 | 9.60E-04 | 4.301E-03 | C16orf45, RBFOX1 |
| 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0.813 | 0.368 | 9.80E-04 | 4.301E-03 | PIAS2, PRKAR1B |
| 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0.820 | 0.417 | 1.27E-03 | 4.790E-03 | RPL19, RPL39 |
| 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0.800 | 0.404 | 1.32E-03 | 4.828E-03 | ATP6V1D, KLC1 |
* Diff. significance: Statistical significance of the avg. PCC brain disease - avg. PCC normal empirically calculated based on the background distribution of 100,000 random gene groups.