Table 1.
Percent composition (%w/w) for OG liposome formulations developed and tested in these studies.
| Ingredients | Prototype | OG/Lipid ratio optimization |
Effect of viscosity agent | Dosing study | Final |
|---|---|---|---|---|---|
| OG | 0.25/0.5/0.75/1 | 0.5 | 0.5 | 0.1/0.3/0.5/,1.0/3.0/6.0 | 1.0 |
| Phosphatidylcholline | 5 | 1/2.5/5/10 | 0.5/1/5/10 | 10 | 10 |
| Propylene glycol | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 |
| Ethanol | 5.00 | 5.00 | 5.00 | 5.00 | 5.00 |
| Vitamin E acetate | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Methylparaben | 0/0.15 | 0.04 | 0.04 | ||
| Propylparaben | 0/0.05 | 0.02 | 0.02 | ||
| BZT | 0 or 0.1 | ||||
| Carbopol® 934 or Ultrez 10 |
0 or 0.4 | ||||
| Citric acid anhydrous | 0.12 | 0.12 | |||
| Sodium citrate | 0.3 | 0.3 | |||
| DI water | qs to 100 | qs to 100 | qs to 100 | qs to 100 | qs to 100 |
qs, quantity sufficient.