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. 2015 Jun 9;5:11100. doi: 10.1038/srep11100

Figure 7. In vivo effects of edaravone and diethyl maleate (DEM) treatments of human umbilical cord mesenchymal stem cells (hUCMSCs) on their therapeutic efficacy in an acute liver failure model induced by D-galactosamine/LPS (Gal/LPS).

Figure 7

(a) Edaravone treatment showed better rescuing effects on NOD/SCID mice death than untreated and DEM-treated hUCMSCs. (b,c) Edaravone treatment showed better ameliorative effects on hepatic histology than untreated and DEM-treated hUCMSCs after liver failure. Yellow arrows indicate typical necro-inflammatory cells. (d) Edaravone increased while DEM decreased the expanded cell number in the host liver after transplantation. (e) Localization of hUCMSCs in the Gal/LPS-challenged mouse liver using PKH immunofluorescnece at day 7 post-infusion. Quantified data also proved the finding. GL, Gal/LPS. Magnification 200x. Bar: 20 μm. “*” “**” “***” mean significant changes (P < 0.05, 0.01, 0.001) between indicated two groups, respectively.