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p53 stabilization requires IE gene expression but not viral DNA replication. HFFF-2 cells were either mock infected or infected with HSV-1 (strain 17+) at an MOI of 1 PFU/cell in the presence or absence (+ and −, respectively) of CHX (final concentration, 10 μg/ml) (A) or ACG (final concentration, 10 μg/ml) (B).
