FIG. 5.
Representative histology of various tissues of EV71-infected mice. Seven-day-old ICR mice were orally inoculated with cell lysate (mock control) or the mouse-adapted EV71 strain (MP4) (5 × 106 PFU/mouse), and tissues were examined histopathologically at 6 dpi as described in Materials and Methods. Typical lesions seen in MP4-infected mice include neuronal loss in ventral horns of the spinal cord (A and B), severe necrotizing myositis (C and D), decreased hematopoiesis in the liver (E and F), splenic atrophy (G and H), and villous blunting in the small intestine (I and J; 1 dpi). Hematoxylin and eosin stain. Magnifications, ×400 (A, B, I, and J), ×100 (C to F), and ×40 (G and H).