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. Author manuscript; available in PMC: 2015 Jun 9.
Published in final edited form as: J Immunol. 2010 Feb 24;184(7):3988–3996. doi: 10.4049/jimmunol.0901657

FIGURE 1.

FIGURE 1

Administration of DSS demonstrated increased susceptibility to experimental colitis in Clcn5 KO mice. Results presented are representative of seven mice from each group. A, DAI was scored from WT and Clcn5 KO mice for weight loss, stool consistency, and bleeding. B, Clinical assessment of acute DSS colitis in WT and Clcn5 KO mice. C, Histological analysis of acute DSS colitis in WT and Clcn5 KO mice by H&E-stained colonic sections (original magnification ×20). D, For detailed histological analysis, colonic sections of WT and Clcn5 KO mice were scored in a blinded fashion as described in Materials and Methods. E, MPO activities in colon from WT and Clcn5 KO mice were determined as described in Materials and Methods. Clcn5 KO mice induced with colitis demonstrated statistically significant elevations in DAI, HAI, and MPO relative to those of WT mice, demonstrating increased susceptibility to acute experimental colitis. *p < 0.05. e, epithelial disruption; i, inflammatory infiltrate; m, lamina muscularis mucosae; s, submucosal edema.