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. Author manuscript; available in PMC: 2015 Jun 9.
Published in final edited form as: J Immunol. 2010 Feb 24;184(7):3988–3996. doi: 10.4049/jimmunol.0901657

FIGURE 2.

FIGURE 2

Distinct cellular cytotoxic and chemotactic patterns identified in Clcn5 KO mice induced with acute experimental colitis. Levels of 16 cytokines were measured simultaneously using a biometric multiplex assay from serum of WT and Clcn5 KO mice with and without acute DSS colitis. Data is presented with mean (+), median (−), and upper and lower quartile values. *p < 0.05; **p < 0.001. A and C, Cytokine pattern in acute colitis of Clcn5 KO mice is represented by a Th1–Th17-polarized (IL-17, IL-12, and IFN-γ) and a strong chemotactic pattern (MIP-1α, KC, and MCP-1) when compared with that of acute colitis in WT mice. B, No significant differences were observed in levels of humoral cytokines and other cellular cytokines and chemokines between WT and Clcn5 KO mice. Of particular significance are the statistically increased levels of IL-6 in untreated Clcn5 KO mice. At least seven mice were used in each group.