FIGURE 1. rs6910730 and rs7759295 are independently associated with neuropathology in ROS and MAP.

In post-mortem neuropathological assessments of ROS and MAP subjects, we visualized neuritic plaques by modified Bielschowsky silver stain and measured Tau tangle density by immunohistochemistry in tissue sections from five brain regions. Using linear regression, we assessed the association between common SNPs in the TREM locus and a normalized measure of NP and Tau tangle density. (A) rs6910730^G was associated with an increased accumulation of NP (n=1001)(p=3.7×10⁻⁴, β=0.13). (B) rs7759295^C was associated with an increased Tau tangle density (n=976)(p=4.9×10⁻⁴, β=−0.33), and this association was not significantly diminished by conditioning on rs6910730 (after conditioning on rs6910730: p=7.7×10⁻⁴, β=0.32). In both panels, the color of a SNP represents the strength of the linkage disequilibrium (measured by r² in the 1000 Genomes EUR March 2012 Release) between the SNP of interest and the lead SNP, rs6910730 or rs7759295, indicated in purple. Red corresponds to an r²≥0.8; orange corresponds to 0.8>r²≥0.6; green corresponds to 0.6>r²≥0.4; light blue corresponds to 0.4>r²≥0.2; dark blue corresponds to 0.2>r²≥0.