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Representative images of the liver in lean (a and c) and diet-induced obesity (DIO) mice (b and d) submitted to chronic intermittent hypoxia (CIH) or control conditions. No significant changes were observed in (a) control-lean. (b) Control-DIO mice presented microvesicular hepatic steatosis. (c) No significant changes were observed in CIH-lean. (d) CIH-DIO mice presented a robust increase in macrovesicular hepatic steatosis and lobular inflammation. H&E, hematoxylin and eosin.
