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Plasma morphine level as a function of morphine consumption for subjects who achieved adequate symptom control (Rx success, ●) and subjects who failed therapy (Rx failure, ○). At the time the second plasma morphine level was measured, plasma morphine level was independent of morphine consumption for patients in both groups, and average plasma morphine levels did not differ between groups (34.7 ± 5.1 vs 29.2 ± 3.2 ng/mL for responders and treatment failures, respectively).
