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. 2015 Jun 3;10:3779–3790. doi: 10.2147/IJN.S83279

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© 2015 Li et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Folate-targeted and nontargeted magnetite particle synthesis.

Notes: (A) Synthesis of ALN-PEG polymer; (B) ALN-PEG-folate; (C) cartoon structure of APM and FAPM; (D) schematic of SMART and folate-modified SMART (FSMART); and (E) an NMR spectrum of conjugated ALN-PEG are shown.

Abbreviations: ALN, alendronate; PEG, polyethylene glycol; APM, ALN-PEG-coated magnetite; FAPM, ALN-PEG-FA-coated magnetite; SMART, small magnetite antiretroviral therapy; NMR, nuclear magnetic resonance; EDC, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; NHS, N-hydroxysuccinimide; NaN₃, sodium azide; Cu, copper; FA, folic acid; DCC, N,N′-dicyclohexylcarbodiimide; USPIO, ultrasmall superparamagnetic iron oxide; PLGA, poly(lactic-co-glycolic acid).