Table S1.
SNP | Population | Genotype frequencies
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Allele frequencies
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Genotype | Freq | Count | Genotype | Freq | Count | Genotype | Freq | Count | Total | Allele | Freq | Count | Allele | Freq | Count | Total | ||
rs12925602 | JPT | G/G | 0.708 | 80 | A/G | 0.265 | 30 | A/A | 0.027 | 3 | 113 | G | 0.841 | 190 | A | 0.159 | 36 | 226 |
CHB | G/G | 0.708 | 97 | A/G | 0.255 | 35 | A/A | 0.036 | 5 | 137 | G | 0.836 | 229 | A | 0.164 | 45 | 274 | |
CHD | G/G | 0.642 | 70 | A/G | 0.339 | 37 | A/A | 0.018 | 2 | 109 | G | 0.812 | 177 | A | 0.188 | 41 | 218 | |
GIH | G/G | 0.802 | 81 | A/G | 0.149 | 15 | A/A | 0.050 | 5 | 101 | G | 0.876 | 177 | A | 0.124 | 25 | 202 | |
CEU | G/G | 0.850 | 96 | A/G | 0.142 | 16 | A/A | 0.009 | 1 | 113 | G | 0.920 | 208 | A | 0.080 | 18 | 226 | |
TSI | G/G | 0.745 | 76 | A/G | 0.255 | 26 | A/A | 0.000 | 0 | 102 | G | 0.873 | 178 | A | 0.127 | 26 | 204 | |
ASW | G/G | 0.750 | 42 | A/G | 0.250 | 14 | A/A | 0.000 | 0 | 56 | G | 0.875 | 98 | A | 0.125 | 14 | 112 | |
LWK | G/G | 0.782 | 86 | A/G | 0.191 | 21 | A/A | 0.027 | 3 | 110 | G | 0.877 | 193 | A | 0.123 | 27 | 220 | |
MKK | G/G | 0.833 | 130 | A/G | 0.160 | 25 | A/A | 0.006 | 1 | 156 | G | 0.913 | 285 | A | 0.087 | 27 | 312 | |
YRI | G/G | 0.789 | 116 | A/G | 0.204 | 30 | A/A | 0.007 | 1 | 147 | G | 0.891 | 262 | A | 0.109 | 32 | 294 | |
MEX | G/G | 0.741 | 43 | A/G | 0.224 | 13 | A/A | 0.034 | 2 | 58 | G | 0.853 | 99 | A | 0.147 | 17 | 116 | |
rs7193788 | JPT | A/A | 0.265 | 30 | A/G | 0.504 | 57 | G/G | 0.230 | 26 | 113 | A | 0.518 | 117 | G | 0.482 | 109 | 226 |
CHB | A/A | 0.285 | 39 | A/G | 0.445 | 61 | G/G | 0.270 | 37 | 137 | A | 0.507 | 139 | G | 0.493 | 135 | 274 | |
CHD | A/A | 0.275 | 30 | A/G | 0.560 | 61 | G/G | 0.165 | 18 | 109 | A | 0.555 | 121 | G | 0.445 | 97 | 218 | |
GIH | A/A | 0.584 | 59 | A/G | 0.366 | 37 | G/G | 0.050 | 5 | 101 | A | 0.767 | 155 | G | 0.233 | 47 | 202 | |
CEU | A/A | 0.690 | 78 | A/G | 0.274 | 31 | G/G | 0.035 | 4 | 113 | A | 0.827 | 187 | G | 0.173 | 39 | 226 | |
TSI | A/A | 0.784 | 80 | A/G | 0.186 | 19 | G/G | 0.029 | 3 | 102 | A | 0.877 | 179 | G | 0.123 | 25 | 204 | |
ASW | A/A | 0.719 | 41 | A/G | 0.246 | 14 | G/G | 0.035 | 2 | 57 | A | 0.842 | 96 | G | 0.158 | 18 | 114 | |
LWK | A/A | 0.691 | 76 | A/G | 0.273 | 30 | G/G | 0.036 | 4 | 110 | A | 0.827 | 182 | G | 0.173 | 38 | 220 | |
MKK | A/A | 0.679 | 106 | A/G | 0.282 | 44 | G/G | 0.038 | 6 | 156 | A | 0.821 | 256 | G | 0.179 | 56 | 312 | |
YRI | A/A | 0.796 | 117 | A/G | 0.190 | 28 | G/G | 0.014 | 2 | 147 | A | 0.891 | 262 | G | 0.109 | 32 | 294 | |
MEX | A/A | 0.741 | 43 | A/G | 0.241 | 14 | G/G | 0.017 | 1 | 58 | A | 0.862 | 100 | G | 0.138 | 16 | 116 | |
rs736719 | JPT | C/C | 0.779 | 88 | C/T | 0.186 | 21 | T/T | 0.035 | 4 | 113 | C | 0.872 | 197 | T | 0.128 | 37 | 226 |
CHB | C/C | 0.679 | 93 | C/T | 0.277 | 38 | T/T | 0.044 | 6 | 133 | C | 0.818 | 224 | T | 0.182 | 50 | 274 | |
CHD | C/C | 0.688 | 75 | C/T | 0.303 | 33 | T/T | 0.009 | 1 | 109 | C | 0.839 | 183 | T | 0.161 | 35 | 218 | |
GIH | C/C | 0.762 | 77 | C/T | 0.228 | 23 | T/T | 0.010 | 1 | 101 | C | 0.876 | 177 | T | 0.124 | 25 | 202 | |
CEU | C/C | 0.699 | 79 | C/T | 0.265 | 30 | T/T | 0.035 | 4 | 113 | C | 0.832 | 188 | T | 0.168 | 38 | 226 | |
TSI | C/C | 0.784 | 80 | C/T | 0.186 | 19 | T/T | 0.029 | 3 | 102 | C | 0.877 | 179 | T | 0.123 | 25 | 204 | |
ASW | C/C | 0.737 | 42 | C/T | 0.228 | 13 | T/T | 0.035 | 2 | 57 | C | 0.851 | 97 | T | 0.149 | 17 | 114 | |
LWK | C/C | 0.700 | 77 | C/T | 0.264 | 29 | T/T | 0.036 | 4 | 110 | C | 0.832 | 183 | T | 0.168 | 37 | 220 | |
MKK | C/C | 0.679 | 106 | C/T | 0.288 | 45 | T/T | 0.032 | 5 | 156 | C | 0.824 | 257 | T | 0.176 | 55 | 312 | |
YRI | C/C | 0.796 | 117 | C/T | 0.190 | 28 | T/T | 0.014 | 2 | 147 | C | 0.891 | 262 | T | 0.109 | 32 | 294 | |
MEX | C/C | 0.776 | 45 | C/T | 0.207 | 12 | T/T | 0.017 | 1 | 58 | C | 0.879 | 102 | T | 0.121 | 14 | 116 | |
rs6565051 | JPT | G/G | 0.133 | 15 | A/G | 0.469 | 53 | A/A | 0.398 | 45 | 113 | G | 0.367 | 83 | A | 0.633 | 143 | 226 |
CHB | G/G | 0.146 | 20 | A/G | 0.416 | 57 | A/A | 0.438 | 60 | 137 | G | 0.354 | 97 | A | 0.646 | 177 | 274 | |
CHD | G/G | 0.148 | 16 | A/G | 0.463 | 50 | A/A | 0.389 | 42 | 108 | G | 0.380 | 82 | A | 0.620 | 134 | 216 | |
GIH | G/G | 0.079 | 8 | A/G | 0.356 | 36 | A/A | 0.564 | 57 | 101 | G | 0.257 | 83 | A | 0.743 | 150 | 202 | |
CEU | G/G | 0.071 | 8 | A/G | 0.354 | 40 | A/A | 0.575 | 65 | 113 | G | 0.248 | 56 | A | 0.752 | 170 | 226 | |
TSI | G/G | 0.108 | 11 | A/G | 0.461 | 47 | A/A | 0.431 | 44 | 102 | G | 0.338 | 69 | A | 0.662 | 135 | 204 | |
ASW | G/G | 0.088 | 5 | A/G | 0.421 | 24 | A/A | 0.491 | 28 | 57 | G | 0.298 | 34 | A | 0.702 | 80 | 114 | |
LWK | G/G | 0.073 | 8 | A/G | 0.355 | 39 | A/A | 0.573 | 63 | 110 | G | 0.250 | 55 | A | 0.750 | 165 | 220 | |
MKK | G/G | 0.052 | 8 | A/G | 0.426 | 66 | A/A | 0.523 | 81 | 155 | G | 0.265 | 82 | A | 0.735 | 228 | 310 | |
YRI | G/G | 0.095 | 14 | A/G | 0.442 | 65 | A/A | 0.463 | 68 | 147 | G | 0.316 | 93 | A | 0.684 | 201 | 294 | |
MEX | G/G | 0.140 | 8 | A/G | 0.509 | 29 | A/A | 0.351 | 20 | 57 | G | 0.395 | 45 | A | 0.605 | 69 | 114 | |
rs7204454 | JPT | G/G | 0.319 | 36 | C/G | 0.540 | 61 | C/C | 0.142 | 16 | 113 | G | 0.588 | 133 | C | 0.412 | 93 | 226 |
CHB | G/G | 0.382 | 52 | C/G | 0.441 | 60 | C/C | 0.176 | 24 | 136 | G | 0.603 | 164 | C | 0.397 | 108 | 272 | |
CHD | G/G | 0.394 | 43 | C/G | 0.486 | 53 | C/C | 0.119 | 13 | 109 | G | 0.638 | 139 | C | 0.362 | 79 | 218 | |
GIH | G/G | 0.158 | 16 | C/G | 0.406 | 41 | C/C | 0.436 | 44 | 101 | G | 0.361 | 73 | C | 0.639 | 129 | 202 | |
CEU | G/G | 0.100 | 11 | C/G | 0.436 | 48 | C/C | 0.464 | 51 | 110 | G | 0.318 | 70 | C | 0.682 | 150 | 220 | |
TSI | G/G | 0.147 | 15 | C/G | 0.598 | 61 | C/C | 0.255 | 26 | 102 | G | 0.446 | 91 | C | 0.554 | 113 | 204 | |
ASW | G/G | 0.263 | 15 | C/G | 0.439 | 25 | C/C | 0.298 | 17 | 57 | G | 0.482 | 55 | C | 0.518 | 59 | 114 | |
LWK | G/G | 0.164 | 18 | C/G | 0.536 | 59 | C/C | 0.300 | 33 | 110 | G | 0.432 | 95 | C | 0.568 | 125 | 220 | |
MKK | G/G | 0.141 | 22 | C/G | 0.449 | 70 | C/C | 0.410 | 64 | 156 | G | 0.365 | 114 | C | 0.635 | 198 | 312 | |
YRI | G/G | 0.284 | 40 | C/G | 0.504 | 71 | C/C | 0.213 | 30 | 141 | G | 0.535 | 151 | C | 0.465 | 131 | 282 | |
MEX | G/G | 0.310 | 18 | C/G | 0.500 | 29 | C/C | 0.190 | 11 | 58 | G | 0.560 | 65 | C | 0.440 | 51 | 116 | |
rs8057927 | JPT | T/T | 0.478 | 54 | C/T | 0.425 | 48 | C/C | 0.097 | 11 | 113 | T | 0.690 | 156 | C | 0.310 | 70 | 226 |
CHB | T/T | 0.478 | 65 | C/T | 0.412 | 56 | C/C | 0.110 | 15 | 136 | T | 0.684 | 186 | C | 0.316 | 86 | 272 | |
CHD | T/T | 0.514 | 56 | C/T | 0.394 | 43 | C/C | 0.092 | 10 | 109 | T | 0.711 | 155 | C | 0.289 | 63 | 218 | |
GIH | T/T | 0.901 | 91 | C/T | 0.089 | 9 | C/C | 0.010 | 1 | 101 | T | 0.946 | 191 | C | 0.054 | 11 | 202 | |
CEU | T/T | 0.876 | 99 | C/T | 0.124 | 14 | C/C | 0 | 0 | 113 | T | 0.938 | 212 | C | 0.062 | 14 | 226 | |
TSI | T/T | 0.853 | 87 | C/T | 0.147 | 15 | C/C | 0 | 0 | 102 | T | 0.926 | 189 | C | 0.074 | 15 | 204 | |
ASW | T/T | 0.632 | 36 | C/T | 0.351 | 20 | C/C | 0.018 | 1 | 57 | T | 0.807 | 92 | C | 0.193 | 22 | 114 | |
LWK | T/T | 0.620 | 67 | C/T | 0.324 | 35 | C/C | 0.056 | 6 | 108 | T | 0.782 | 169 | C | 0.218 | 47 | 216 | |
MKK | T/T | 0.692 | 108 | C/T | 0.250 | 39 | C/C | 0.058 | 9 | 156 | T | 0.817 | 255 | C | 0.183 | 57 | 312 | |
YRI | T/T | 0.623 | 91 | C/T | 0.336 | 49 | C/C | 0.041 | 6 | 146 | T | 0.791 | 231 | C | 0.209 | 61 | 292 | |
MEX | T/T | 0.807 | 46 | C/T | 0.175 | 10 | C/C | 0.018 | 1 | 57 | T | 0.895 | 102 | C | 0.105 | 12 | 114 | |
rs8049308 | JPT | T/T | 0.455 | 20 | C/T | 0.500 | 22 | C/C | 0.045 | 2 | 44 | T | 0.705 | 62 | C | 0.295 | 26 | 88 |
CHB | T/T | 0.364 | 16 | C/T | 0.477 | 21 | C/C | 0.159 | 7 | 44 | T | 0.602 | 53 | C | 0.398 | 35 | 88 | |
CEU | T/T | 0.650 | 39 | C/T | 0.333 | 20 | C/C | 0.017 | 1 | 60 | T | 0.817 | 98 | C | 0.183 | 22 | 120 | |
YRI | T/T | 0.583 | 35 | C/T | 0.383 | 23 | C/C | 0.033 | 2 | 60 | T | 0.775 | 93 | C | 0.225 | 27 | 120 |
Note: Genotype frequencies and allele frequencies data were determined by the HapMap database (HapMap data release 28, Phase 2+3, August 10), on NCBI B36 assembly, dbSNP b126 (http://hapmap.ncbi.nlm.nih.gov/).
Abbreviations: ASW, African ancestry in southwest USA; CDH13, cadherin13; CEU, residents of UT, USA with Northern and Western European ancestry, from the Centre d’Etude du Polymorphisme Humain collection; CHB, Han Chinese in Beijing, People’s Republic of China; CHD, Chinese in metropolitan Denver, CO, USA; freq, frequency; GIH, Gujarati Indians in Houston, TX, USA; JPT, Japanese in Tokyo, Japan; LWK, Luhya in Webuye, Kenya; MEX, Mexican ancestry in Los Angeles, CA, USA; MKK, Maasai in Kinyawa, Kenya; SNP, single nucleotide polymorphism; TSI, Tuscan in Italy; YRI, Yoruba in Ibadan, Nigeria.