Table 1.

Association between CDH13 SNPs with schizophrenia

Sample	SNP ID positiona	Phen	Genotype distribution			Minor allele		P-value			Power	OR (95% CI)
			MM	Mm	mm	MAF	Allele	HWE	Genotypeb	Allelec
rs12925602, rs7193788, rs736719, rs6565051, and rs7204454
First set SCZ, n=665 CON, n=760	rs12925602	SCZ	418	198	29	0.198	A	0.428	0.708	0.696	0.059	0.97 (0.80–1.16)
	81213402	CON	471	255	26	0.204		0.281		(0.991)
	rs7193788	SCZ	203	304	139	0.449	G	0.269	0.327	0.369	0.099	1.08 (0.93–1.25)
	81213661	CON	234	384	132	0.432		0.241		(0.815)
	rs736719	SCZ	515	121	5	0.102	T	0.643	0.130	0.138	0.188	0.83 (0.66–1.06)
	81214146	CON	575	161	9	0.12		0.698		(0.436)
	rs6565051	SCZ	275	275	96	0.363	G	0.062	0.905	0.946	0.050	0.99 (0.85–1.16)
	81216229	CON	310	337	105	0.364		0.479		(1.000)
	rs7204454	SCZ	268	284	93	0.364	C	0.271	0.473	0.454	0.085	1.06 (0.91–1.24)
	81216695	CON	315	342	92	0.350		0.982		(0.892)
Second set SCZ, n=677 CON, n=667	rs12925602	SCZ	433	215	27	0.199	A	1.000	0.3505	0.3476	0.100	1.10 (0.91–1.33)
	81213402	CON	444	196	25	0.185		0.629		(0.786)
	rs7193788	SCZ	220	329	128	0.432	G	0.845	0.2825	0.6671	0.060	1.09 (0.94–1.27)
	81213661	CON	244	316	123	0.424		0.575		(0.985)
	rs736719	SCZ	522	140	15	0.126	T	0.180	0.1495	0.1455	0.176	1.19 (0.94–1.51)
	81214146	CON	528	131	6	0.108		0.669		(0.445)
	rs6565051	SCZ	265	308	101	0.378	G	0.497	0.3395	0.3389	0.104	0.93 (0.79–1.08)
	81216229	CON	237	324	100	0.396		0.600		(0.774)
	rs7204454	SCZ	289	296	83	0.346	C	0.639	0.7327	0.7267	0.056	0.97 (0.83–1.14)
	81216695	CON	288	279	93	0.352		0.068		(0.993)
Combined SCZ, n=1,342 CON, n=1,427	rs12925602	SCZ	851	413	56	0.199	A	0.555	0.729	0.738	0.058	1.02 (0.90–1.17)
	81213402	CON	915	451	51	0.195		0.690		(0.994)
	rs7193788	SCZ	423	633	267	0.440	G	0.334	0.161	0.366	0.098	1.08 (0.97–1.20)
	81213661	CON	478	700	255	0.428		0.670		(0.811)
	rs736719	SCZ	1,037	261	20	0.114	T	0.511	0.999	0.992	0.050	1.00 (0.85–1.18)
	81214146	CON	1,103	292	15	0.114		0.462		(1.000)
	rs6565051	SCZ	540	583	197	0.371	G	0.067	0.503	0.520	0.072	0.96 (0.86–1.07)
	81216229	CON	547	661	205	0.379		0.909		(0.931)
	rs7204454	SCZ	557	580	176	0.355	C	0.243	0.806	0.788	0.056	1.01 (0.91–1.13)
	81216695	CON	603	621	185	0.351		0.245		(0.997)
rs8049308 (as the substitute for rs8057927)
First set SCZ, n=665 CON, n=760	rs8049308	SCZ	309	267	69	0.314	C	0.357	0.634	0.630	0.066	1.04 (0.89–1.22)
	81252503	CON	363	313	72	0.305		0.753		(0.658)

Notes:

^aSNP ID number and positions are available at http://hapmap.ncbi.nlm.nih.gov/.

^bGenotypic P-values were tested with the Cochran-Armitage test for trend.

^cAllelic P-values were tested with χ²; corrections for multiple comparisons are in parentheses (for 10,000 permutations).

Abbreviations: CDH13, cadherin13; CI, confidence interval; CON, control; HWE, Hardy–Weinberg equilibrium; M, major allele; m, minor allele; MAF, minor allele frequency; OR, odds ratio; Phen, phenotype; SCZ, schizophrenia; SNP, single nucleotide polymorphism; SNP ID, single nucleotide polymorphism identification.