Table S3.
Putative transcription factor binding site in each SNP on the promoter region of CDH13
| SNP ID | Allele | Sequence | Predicted TF | Binding site | Function |
|---|---|---|---|---|---|
| rs12925602 | A | TCTGCCTACATC[A] AGGAAATTCAGA |
c-Ets- | ATCAAGGAAATT | Regulates numerous genes and involved in stem cell development, cell senescence and death, and tumorigenesis |
| GATA-1 | CATCAAGGA | Regulates the switch of fetal hemoglobin to adult hemoglobin for erythroid development | |||
| CdxA | CA TCAAG | A transcription factor that binds to DNA to regulate the expression of genes, in particular the Hox genes | |||
| G | TCTGCCTACATC[G] AGGAAATTCAGA |
c-Ets- | ATCGAGGAAATT | Regulates numerous genes and involved in stem cell development, cell senescence and death, and tumorigenesis | |
| GATA-1 | CATCGAGGA | Regulates the switch of fetal hemoglobin to adult hemoglobin for erythroid development | |||
| rs7193788 | A | GCACGCAGCAGT[A] AAAATACAGAAA |
CdxA | TAAAAATAAAAATA | A transcription factor that binds to DNA to regulate the expression of genes, in particular the Hox genes |
| AhR/Ar | GAGCACGCAGCAGTAA | A ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons | |||
| Sox5 | GTAAAAATAC | A transcription factor involved in the regulation of embryonic development and in the determination of cell fate | |||
| G | GCACGCAGCAGT[G] AAAATACAGAAA |
AhR/Ar | ACGCAGCAGTGAAAA | A ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons | |
| rs736719 | C | CAGGAAGAAACA[C] GAAGCAGTGTTT |
SRY | AAACACG | A transcription factor and a member of the HMG-box family of DNA binding proteins, which may directly generate some male-specific properties of the brain |
| T | CAGGAAGAAACA[T] GAAGCAGTGTTT |
SRY | AAACATG | A transcription factor and a member of the HMG-box family of DNA binding proteins, which may directly generate some male specific properties of the brain | |
| HNF-3b | GAAGAAACA TGA | A transcription factor and a member of the forkhead class of DNA-binding proteins | |||
| rs6565051 | A | ACCTTCCCTGGA[A] TGGAGAAAAGTC |
C/EBPb | GAATG GAGAAAAGT | A transcription factor that can bind as a homodimer to certain DNA regulatory regions and can also form heterodimers with other C/EBP |
| G | ACCTTCCCTGGA[G] TGGAGAAAAGTC |
C/EBPb | GAGTG GAGAAAAGT | A transcription factor that can bind as a homodimer to certain DNA regulatory regions and can also form heterodimers with other C/EBP | |
| MZF1 | AGTG GAGA | A member of the SCAN domain family transcription factors that form dimers through their highly conserved SCAN motifs | |||
| rs7204454 | C | GTGAGTTCAGTA[C] AATTTGTGTTTT |
CdxA | TACAATT | A transcription factor that binds to DNA to regulate the expression of genes, in particular the Hox genes |
| G | GTGAGTTCAGTA[G] AATTTGTGTTTT |
CdxA | TAGAATT | A transcription factor that binds to DNA to regulate the expression of genes, in particular the Hox genes |
Abbreviations: CDH13, cadherin13; SNP, single nucleotide polymorphism; SNP ID, single nucleotide polymorphism identification; TF, transcription factor.