Table S4.

The MS qualitative analysis results of HGF (the mass spectrometry data of main eight ingredients)

Peak number	Retention time (min)	Compound	Molecular formula	Molecular weight (MW)	Measured value	Error value (ppm)	Matching score	Adduction
1	10.633	Liquiritin	C21H22O9	418.3940	417.1185	−1.44	91.84	[M−H]−
2	12.758	Tectoridin	C22H22O11	462.4035	461.1089	0.00	96.79	[M−H]−
3	39.25	Luteolin	C15H10O6	286.23	285.0402	−1.05	89.06	[M−H]−
4	44.243	Aloe-emodin	C15H10O5	270.23	271.3651	2.41	87.80	[M+H]+
5	45.598	Rhein	C15H8O6	284.22	283.0246	−0.71	89.20	[M−H]−
6	64.0553	Emodin	C15H10O5	270.23	269.0447	−2.97	92.08	[M−H]−
7	74.158	Chrysophanol	C15H10O4	254.23	253.0498	−3.16	90.23	[M−H]−
8	78.692	Physcion	C16H12O5	284.27	283.0606	−2.12	82.12	[M−H]−

Abbreviations: MS, mass spectrometry; HGF, Huang Gan formula.