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. 2015 Jun 3;9:2855–2865. doi: 10.2147/DDDT.S76358

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© 2015 Xu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Relationship between the frequency of RUNX3 hypermethylation and pathological types.

Notes: (A) NSCLC patients (n=657) with smoking status pooled from eight studies. Aberrant RUNX3 hypermethylation was not strongly associated with smoking status in NSCLC patients (OR 0.51, CI 0.24–1.08, P=0.08). (B) The pooled OR from eleven studies including 271 squamous cell carcinoma and 389 adenocarcinoma (OR 0.41, CI 0.19–0.89, P=0.02), indicating that RUNX3 hypermethylation plays a more important role in the pathogenesis of adenocarcinoma.

Abbreviations: CI, confidence interval; OR, odds ratio; M–H, Mantel–Haenszel; NSCLC, non-small cell lung cancer.