FIG. 5.

Delayed clearance of WNV from the brains of surviving CD8^−/− and MHC-Ia^−/− mice. Wild-type (WT), CD8^−/−, and MHC class Ia^−/− mice were infected with 10² PFU of WNV. Surviving animals were euthanized at 28 or 35 days after infection, and brains were analyzed for infectious virus by plaque assay as described in the Fig. 2 legend. Data are shown as the average PFU per gram of tissue and reflect three to five mice per time point.