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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: CA Cancer J Clin. 2014 Aug 7;64(5):311–336. doi: 10.3322/caac.21244

Figure 4. MicroRNAs as targets for anticancer drug therapy.

Figure 4

In order to restore tumor suppressor proteins levels, oncomiRs can be targeted with therapies such as antagomirs or LNAs anti-miRs. When aiming to target oncogenic proteins, the levels of tumor suppressor-miRNAs can be restored by using miRNA mimics, or alternatively through siRNA delivery against the oncogenic target. A direct messenger RNA inhibition of oncogenic proteins can be obtained also through a ribozyme-mediated translation inhibition.