Table 2.
Most commonly reported treatment-related adverse events (AEs) of any grade or Grade ≥3 (N = 1671)
| No. of patients (%) |
||
|---|---|---|
| AE | Any grade | Grade ≥3 |
| Any AE | 1594 (95) | 1163 (70) |
| Platelet count decreaseda | 1019 (61) | 574 (34) |
| Hand–foot syndrome | 616 (37) | 93 (6) |
| Hypothyroidism | 593 (35) | 44 (3) |
| Hypertension | 584 (35) | 168 (10) |
| White blood cell count decreased | 547 (33) | 169 (10) |
| Stomatitis | 281 (17) | 21 (1) |
| Diarrhea | 271 (16) | 34 (2) |
| Pyrexia | 234 (14) | 20 (1) |
| Neutrophil count decreaseda | 224 (13) | 131 (8) |
| Decreased appetite | 211 (13) | 57 (3) |
| Anemiaa | 193 (12) | 76 (5) |
| Thrombocytopeniaa | 147 (9) | 83 (5) |
| Lipase increased | 195 (12) | 79 (5) |
| Malaise | 173 (10) | 53 (3) |
| Hemoglobin decreaseda | 91 (5) | 24 (1) |
| Neutropeniaa | 33 (2) | 24 (1) |
aRelated AE terms (e.g. platelet count decreased and thrombocytopenia) reflect identification by laboratory abnormality data or physician assessment, respectively.