Table 2. Comparison of methylation status of gene promoter in cervical samples with different diagnosis—only statistically significant (Fisher’s exact test) increased methylation changes are presented.
| Hypermethylation (N) | Gene promoter | p |
|---|---|---|
| LSIL/CIN1 (40) vs. normal (40) | C13ORF18 | 0.036738 |
| HSIL/CIN2 (39) vs. normal (40) | C13ORF18 | 0.036738 |
| HSIL/CIN3 (42) vs. normal (40) | CCNA1 | 0.010994 |
| HSIL/CIN2 (39) vs. LSIL/CIN1 (40) | RARβ2 | 0.024696 |
| TWIST1 | 0.001030 | |
| HSIL (81) vs. normal (40) | CCNA1 | 0.042593 |
| C13ORF18 | 0.043737 | |
| LSIL + HSIL (121) vs. normal (40) | CCNA1 | 0.023742 |
| C13ORF18 | 0.022603 | |
| CC (10) vs. normal (40) | CCNA1 | 0.000086 |
| C13ORF18 | 0.000001 | |
| hTERT1 | 0.000001 | |
| hTERT2 | 0.000866 | |
| TWIST1 | 0.003709 | |
| CC (10) vs. HSIL/CIN3 (42) | CCNA1 | 0.031319 |
| C13ORF18 | 0.000107 | |
| hTERT1 | 0.000090 | |
| hTERT2 | 0.000067 | |
| TWIST1 | 0.000969 | |
| CC (10) vs. LSIL + HSIL (121) | CCNA1 | 0.003007 |
| C13ORF18 | 0.000070 | |
| RARβ2 | 0.042019 | |
| hTERT1 | 0.000017 | |
| hTERT2 | 0.000026 | |
| TWIST1 | 0.000031 |
LSIL, low-grade squamous cell intraepithelial lesion; HSIL, high-grade squamous cell intraepithelial lesion; CIN, cervical intraepithelial neoplasia; CC, cervical cancer.