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. Author manuscript; available in PMC: 2016 Jun 3.
Published in final edited form as: Tetrahedron Lett. 2015 Jun 3;56(23):3653–3657. doi: 10.1016/j.tetlet.2015.04.125

Table 1.

Thermodynamic data of NP1-NP7 for binding to CB[7]

Guest Ka(M−1) ΔG (kcal/mol) ΔH (kcal/mol) −TΔS
(kcal/mol)		 N
NP1:H 1.6(±0.32)×105 −7.23 −11.29(±0.49) 4.06 69.4(±2.2)
NP2:tBu 7.23(±0.65)×104 −6.74 −9.06(±0.22) 2.32 96.1(±1.68)
NP3:CH2NH2 2.76(±0.18)×105 −6.61 −10.1(±0.11) 3.49 73.1(±0.54)
NP4:OMe 2.99(±0.31)×105 −7.59 −6.6(±0.1) −0.99 84.2 (±0.89)
NP5:F 2(±0.19)×105 −7.35 −6.59(±0.14) −0.76 54.2(±0.84)
NP6:CN 1.32(±0.69)×106 −8.47 −4.17(±0.2) −4.30 54.5(±1.74)
NP7:NO2 3.76(±0.49)×105 −7.73 −5.06(±0.09) −2.67 68.5(±0.91)