Table 2. Comparison of PRUNET with similar available software.

	CellNOptR	SigNetTrainer	XPRED	PRUNET
EMT	Computation time: 0 h 0 m 4 s Score = 1	Computation time: 0 h 0 m 0,47 s Score = 1	Computation time: 0 h 2 m 30 s Score = 1	Computation time: 0 h 0 m 5,6 s Score = 1
Th1-Th2		Computation time: 0 h 0 m 3,7 s Score = 0,51	Computation time: 176 h 47 m 34 s Score = 0,90	Computation time: 0 h 7 m 25 s Score = 0,88
iPSC			Computation time: 63 h 33 m 45 s Score = 0,94	Computation time: 0 h 2 m 17 s Score = 0,95
hESC-cardiomyocytes			Computation time: 17 h 30 m 0 s Score = 0,83	Computation time: 0 h 1 m 37 s Score = 0,82

Scores represent the match between predicted and real phenotypes; a score of 1 represents a full agreement between training set and model predictions, while a score of 0.5 reflects a correct description of 50% of the training set.