Table 1. Genes that promote Legionella pneumophila iron acquisition.
| Gene | 130b ORF† | Paris ORF† | Phil-1 ORF† | Role in iron acquisition |
|---|---|---|---|---|
| ccmC ‡ | lpw09401 | lpp0920 | lpg0858 | Legiobactin production |
| cyc4 | lpw01241 | lpp0138 | lpg0124 | Legiobactin production |
| feoB | lpw29101 | lpp2711 | lpg2657 | Ferrous iron uptake |
| frgA | lpw30551 | lpp2846 | lpg2800 | Putative siderophore synthetase |
| fur | lpw03201 | lpp0438 | lpg0232 | Transcriptional regulator |
| hbp | lpw00251 | lpp0024 | lpg0024 | Hemin-binding protein |
| hisC2 | lpw20551 | lpp1979 | lpg1998 | HGA production |
| hmgA | lpw13001 | lpp1248 | lpg1285 | HGA degradation |
| iraB | lpw08291 | lpp0812 | lpg0746 | Putative peptide transporter |
| iroT/mavN | lpw30711 | lpp2867 | lpg2815 | Ferrous iron uptake |
| lbtA | lpw13341 | lpp1280 | lpg1325 | Legiobactin biosynthesis |
| lbtB | lpw13331 | lpp1279 | lpg1324 | IM export of legiobactin |
| lbtC | lpw13321 | lpp1278 | lpg1323 | IM import of legiobactin |
| lbtU | lpw13361 | lpp1281 | lpg1326 | OM receptor for legiobactin |
| lly | lpw24691 | lpp2232 | lpg2278 | HGA production |
| mcoL | lpw03531 | lpp0339 | lpg0265 | Multicopper oxidase |
| phhA | lpw28991 | lpp2700 | lpg2647 | HGA production |
| proA/mspA | lpw05471 | lpp0532 | lpg0467 | Degrades transferrin |
| tatB | lpw31801 | lpp2974 | lpg2906 | Growth on low-iron media |
†
The ORF designations are derived from the genome sequencing data that have been recently reported for L. pneumophila strains 130b, Paris and Philadelphia-1 (Phil-1) [23–25]. Utilizing the ORF designations listed in this table, the corresponding ORFs in L. pneumophila strains Alcoy, Corby and Lens can been obtained by visiting the National Center for Biotechnology Information (NCBI) [26] or the Legionella genome website [27].
‡
The entire ccm operon is implicated in iron acquisition, but for sake of brevity, only the ccmC gene is listed here.
HGA: Homogentisic acid; IM: Inner membrane; OM: Outer membrane; ORF: Open reading frame.