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. 2015 Jun 9;65(6):562–570. doi: 10.1097/FJC.0000000000000224

FIGURE 6.

FIGURE 6

Effect of SIRT1 overexpression on hypoxia-induced pulmonary hypertension (HPH) rats. SIRT-1 expression (A) in pulmonary artery tissues form HPH rats was increased significantly at 8 days after intratracheal administration of Ad.SIRT1 or Ad.GFP (1 week of hypoxia). SIRT-1 is expressed relative to β-actin. Overexpression of SIRT1 decreased mPAP (B) in HPH rats. Values are mean ± standard error of the mean (n = 6). *P < 0.05, **P < 0.01 versus HPH + Ad.GFP 1w or 2w using an unpaired Student 2-tailed t test.