Table 3.
Cytotoxicities of the ferrocenoyl esters studied on MCF-7 breast cancer and HT-29 colon cancer cell lines, as determined by MTT assay after 72 h of drug exposure. IC50 values based on quadruplicate experiments and standard deviation in parenthesis. n/a is non-active
| Complex | IC50 × 10−6 M, MCF-7 | IC50 × 10−6 M, HT-29 |
|---|---|---|
| Ferocenoyl (3β,5Z,7E,22E)-9,10-secoergosta5,7,10(19),22-tetraen-3-olate | 1326(110) | 346(50) |
| Ferrocenoyl 17β-hydroxy-estra-1,3,5(10)-trien-3-olate | 9(2) | 24.4(6) |
| Ferrocenoyl 3β-estra1,3,5(10)-trien-17-one-3-olate | 108(7) | n/a |
| Ferrocene | 1500 | 360 |
| Ferrocenium tetrafluoroborate | 150 | 180 |