Table 1.

Genome-wide significant SNPs at 16p11.2.

SNP	BP (hg19)	Closest Gene	Minor /Major Allele	Dis MAF cases	Dis MAF controls	Dis OR	Dis P	Rep P	Meta OR	Meta P
rs750953	31094089	ZNF646	C/T	0.0061	0.000102	66.7	2.05×10−6	1.84×10−3	24.91	4.25×10−8
rs929867	31191482	FUS	A/G	0.00926	0.000102	89.8	6.21×10−9	5.50×10−3	37.33	5.49×10−10
rs7192718	31237920	TRIM72*	T/C	0.00915	0.000128	67.94	1.15×10−8	2.91×10−4	33.37	3.64×10−11
rs10871455	31238690	TRIM72*	T/G	0.00915	0.000102	87.84	7.39×10−9	2.89×10−4	36.61	3.19×10−11
rs12934814	31239855	TRIM72*	T/C	0.00943	0.000128	72.13	7.11×10−9	2.42×10−4	37.9	1.65×10−11
rs4889637	31258238	ITGAM*	C/T	0.00915	0.000128	72.23	7.54×10−9	2.77×10−4	35.19	2.35×10−11
rs4889641	31265541	ITGAM*	A/G	0.00915	0.000103	87.6	7.55×10−9	2.89×10−4	37.29	3.11×10−11
rs8063978	31271700	ITGAM	C/T	0.00938	0.000128	70.39	9.16×10−9	5.64×10−3	32.76	6.67×10−10
rs4889541	31274551	ITGAM	T/C	0.00915	0.000128	68.29	1.12×10−8	7.98×10−3	30.51	1.29×10−9
rs9929801	31283472	ITGAM	C/T	0.00915	0.000744	12.12	4.88×10−5	1.34×10−4	9.22	2.96×10−8
rs8045402	31308281	ITGAM	T/C	0.00915	0.000154	58.55	1.39×10−8	3.38×10−5	30.34	4.73×10−12
rs8056264	31332655	ITGAM	T/C	0.00915	0.000128	73.24	6.79×10−9	2.96×10−4	35.38	2.31×10−11
rs11574629	31362892	ITGAX*	G/A	0.00915	0.000103	87.75	7.44×10−9	3.28×10−4	37.26	3.50×10−11

^*Not directly on gene;

BP=base pair; Dis MAF cases=minor allele frequency in cases of the discovery cohort; Dis MAF controls=minor allele frequency in controls of the discovery cohort; Dis OR=odds ratio in the discovery cohort; Dis P=P-value in the discovery cohort; Rep P=P-value in the replication cohort; Meta OR= odds ratio in the meta-analysis; Meta P= P-value in the meta-analysis.