Fig. 1.

Metabolic state, food intake, and body weight differences between Restricted mice and ad-libitum fed Controls (A) Metabolic states of Control and Restricted mice in 24 h feeding cycle. Restricted mice gorge all food rations shortly after presentation and therefore experience a brief “fed” period and an extended “fasted” period until food is provided the following day. Control mice nibble throughout dark hours and in short bouts during light hours and therefore effectively remain in a constant “fed” state. (B) Food intakes and (C) Body weights during food restriction (first 5 days) and refeeding. Values represent means ± s.e.m. (Control, n=10; Restricted, n=20). Food intakes were evaluated by Mann-Whitney test and body weights by Student’s t-test. Asterisks indicate statistically significant differences, p < 0.05.