Table I.
AMD3100 mobilizes most leukocyte subsets to blood in mice.
| Cell Type | Treatment | |||
|---|---|---|---|---|
| PBS (Mean±SEM) | AMD3100 (Mean±SEM) | Fold Increase | P value | |
| WBCa) | 1700±151 | 8100±1022 | 4.8 | .0001 |
| ANC | 256±96 | 2313±294 | 9.0 | < .0001 |
| ALC | 1154±141 | 5210±460 | 4.5 | < .0001 |
| AMC | 158±22 | 556±87 | 3.5 | .0012 |
| CD3+ T cells | 406±36 | 1522±138 | 3.7 | < .0001 |
| CD3+ CD44low/neg cells | 373±33 | 1275±93 | 3.4 | < .0001 |
| CD3+ CD44high cells | 33±11 | 272±55 | 8.2 | .0012 |
| CD4+ T cells | 222±19 | 605±55 | 2.7 | < .0001 |
| CD4+CD44low/neg T cells | 202±17 | 515±40 | 2.5 | < .0001 |
| CD4+CD44high T cells | 13±4 | 91±17 | 7 | .0011 |
| CD8+ T cells | 136±15 | 718±104 | 5.3 | .0002 |
| CD8+CD44low/neg T cells | 130±14 | 620±76 | 4.8 | < .0001 |
| CD8+CD44high T cells | 5±1 | 88±19 | 17.6 | .0006 |
| B220+ B cells | 278±53 | 1546±245 | 5.6 | .0008 |
| B220+CD27+ Memory | 72±22 | 218±54 | 3 | .0453 |
| B220+CD27− | 251±27 | 1329±195 | 5.3 | .0016 |
| CD11b+Ly6Chigh Inflammory Monocytes | 30±10 | 159 ±28 | 5.3 | .0016 |
| CD11b+Ly6Clow Resident Monocytes | 129±14 | 397±69 | 3 | .0034 |
a)
The numbers of cells/μl blood in 5–6 mice 2.5 hours after treatment are shown.
SEM, standard error of the mean; CD, cluster of differentiation; ANC, absolute neutrophil count; AMC, absolute monocyte count; ALC, absolute lymphocyte count.