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Effect of the mono- and bis-epipodophyllotoxins on induction of apoptosis in K562 cells. Treatment of K562 cells with 1 μM 7d, 6d or 7c, significantly, and progressively, increased caspase 3/7 activity relative to untreated controls. The results are averages (∀ SE) of four wells (eight for the control). Significance relative to the untreated controls: *p < 0.001. rlu is relative luminescent units. The results are typical of experiments carried out on two different days.
