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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2015 May 4;23(13):3175–3182. doi: 10.1016/j.bmc.2015.04.068

Scheme 1. Reagents and conditions.

Scheme 1

(a) i. RNCO, DMF, 67%–74% or ii. RNH2, CDI, DMF, 70 °C, 33%; (b) Pd black, H2, EtOH/CHCl3, 49%–86%; (c) TEMPO, BAIB, CH2Cl2/H2O, 87%; (d) RNH2, HCTU, DIPEA, DMF, 53%–87 %; (e) AlCl3, dimethylaniline, CH2Cl2, 11%–15%.