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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2015 Apr 9;23(13):3603–3617. doi: 10.1016/j.bmc.2015.04.006

Figure 5.

Figure 5

Subcellular localization of compounds 2 and 2a in lung tumor fibroblasts. Primary cultures of tumor-derived fibroblasts were transduced with vectors encoding ER-GFP, Golgi-GFP or Peroxisome-RFP. After 24 h, the cells were incubated for 4 hours with compound 2 or compound 2a. Thirty min prior to the end of incubation, separate cultures were stained with Mito-tracker green or Lysotracker green. All cultures were analyzed by phase contrast and fluorescent microcopy at 400×. All organelle markers are colorized in green, and fluorescence for compounds 2 and 2a is shown in red.