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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Bioorg Med Chem. 2015 Apr 9;23(13):3603–3617. doi: 10.1016/j.bmc.2015.04.006

Figure 7.

Figure 7

Cellular export of carboxylic acid derivatives controled by ABCG2. Primary cultures of ABCG2-positive L352 epithelial cells were incubated for 30 min at 37° in serum-free medium containing 3.2 µM compounds 2 (PS 2), 2a (PS 2a) or 9a (PS 9a). The cells were washed and incubated for 4 hours in compound-free medium containing 10% FBS and either 0 or 10 µM imatinib mesylate. Cell-associated compounds were determined by fluorescence microscopy at 400× magnification using identical camera setting.