Table 3.

Differences on study outcomes between APOE ε4-positive and ε4-negative subjects, stratified by outcome and time after APOE genotype and AD risk disclosure. Positive numbers indicate greater anxiety, depression, or test-related distress among ε4-positive subjects than ε4-negative subjects. P values represent a post-hoc test, using linear models, that scores differ by APOE result after adjusting for randomization, age, sex, race, and education.^*

Time point	Anxiety (BAI) Δ (95% CI)	p	Depression (CES-D) Δ (95% CI)	p	Test-related Distress (IES) Δ (95% CI)	p
12 mo	0.2 (−0.9 to 1.4)	0.69	−0.3 (−1.8 to 1.3)	0.74	2.4 (0.6 to 4.2)	0.01
6 mo	0.6 (−0.6 to 1.8)	0.32	0.1 (−1.6 to 1.8)	0.89	3.0 (0.9 to 5.1)	<0.01
6 wk	0.4 (−0.8 to 1.5)	0.55	0.5 (−1.2 to 2.2)	0.55	4.9 (2.9 to 6.9)	<0.01

^*Plus-minus values are means ± standard errors. CI are confidence intervals. Scores were adjusted for age, education, sex, and race.