Skip to main content
. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Vet Pharmacol Ther. 2014 Dec 9;38(4):375–382. doi: 10.1111/jvp.12194

Table 3.

Pharmacokinetic parameters for the active metabolite of tramadol, O-desmethyltramadol in rhesus macaques (n=4) after IV bolus administration of 1.50 mg/kg tramadol.

Parameter Unit Rhesus Macaque 1 Rhesus Macaque 2 Rhesus Macaque 3 Rhesus Macaque 4 Median (Range)
MRTinf min 281 281 339 382 310 (281-382)
AUCinf min*ng/mL 746 960 913 1,072 937 (746-1,072)
AUC0-inf min*ng/mL 746 960 913 1072 937 (746-1072)
AUC%extrap % 8.29 10.2 12.2 17.3 11.2 (8.3-17.3)
AUMCinf min*min*ng/mL 209,852 270,396 309,462 409,149 289,929 (209,852-409,149)
λz 1/min 0.005 0.004 0.005 0.003 0.004 (0.003-0.005)
t1/2λz min 149 167 144 204 159 (144-204)
Cmax ng/mL 2.00 2.57 1.88 2.73 2.28 (1.88-2.73)
Tmax Min 180 60 240 180 180 (60-240)

Refer to Tables 1 and 2 for key.