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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: J Vet Pharmacol Ther. 2014 Dec 9;38(4):375–382. doi: 10.1111/jvp.12194

Table 4.

Pharmacokinetic parameters for the active metabolite of tramadol, O-desmethyltramadol in rhesus macaques (n=4) after PO administration of 3.00 mg/kg tramadol.

Parameter Unit Rhesus Macaque 1 Rhesus Macaque 2 Rhesus Macaque 3 Rhesus Macaque 4 Median (Range)
MRTinf min 194 282 250 339 266 (194-339)
AUCinf min*ng/mL 2,347 2,336 2,648 3,235 2,497 (2,336-3,235)
AUC0-inf min*ng/mL 2,347 2,336 2,648 3,235 2,497 (2,336-3,235)
AUC%extrap % 1.39 10.8 4.41 13.1 7.61 (1.39-13.1)
AUMCinf min*min*ng/mL 454,830 659,387 663,135 1,097,522 661,261 (454,830-1,097,522)
λz 1/min 0.009 0.004 0.006 0.004 0.005 (0.004-0.009)
t1/2λz min 81.5 162 115 165 138 (82-165)
Cmax ng/mL 14.9 9.37 9.46 13.0 11.2 (9.37-14.9)
Tmax Min 120 90 120 120 120 (90-120)

Refer to Tables 1 and 2 for key.