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Evolution of the cross-bridge model of muscle contraction. (A) Original 2-state model proposed by Huxley (1957). (B) Multi-state cross-bridge model with rotating head as proposed initially by Huxley (1969) and mathematically described by Huxley and Simmons (1971). (C) Multi-state model based on the atomic structure of cross-bridges and actin attachment sites as proposed by Rayment et al. (1993).
