Table 1.
Mutations in zebrafish hematopoietic and vascular genes shown in Figure 1 are detailed here. Reference listed is the first to clone the mutation. If the given mutation is unconfirmed, the reference is for the hematovascular expression of the conserved gene.
| Gene Name | Mutant (abbreviation) | Original Isolation Method | Cloning/Expression Reference |
|---|---|---|---|
| (unknown) | cloche (clo) | ENU screen | (Stainier et al., 1995) |
| (unknown) | bloodless (bls)/sort-of-bloodless (sob) | Insertional Mutagenesis | (Liao et al., 2002) |
| (unknown) | grenache (gre) | ENU screen | (Ransom et al., 1997) |
| (unknown) | thunderbird (tbr) | ENU screen | (Ransom et al., 1997) |
| (unknown) | assam (asm) | ENU-EP screen (targeted: T-cells) | (Trede et al., 2008) |
| (unknown) | camomile (cam) | ENU-EP screen (targeted: T-cells) | (Trede et al., 2008) |
| (unknown) | jasmine (jas) | ENU-EP screen (targeted: T-cells) | (Trede et al., 2008) |
| (unknown) | oolong (oln) | ENU-EP screen | (Trede et al., 2008) |
| activin A receptor, type 1 like (acvr1l; alk8) | lost-a-fin (laf) | ENU screen | (Bauer et al., 2001) |
| cadherin5/VE-Cadherin (cdh5) | (Helker et al., 2013) | ||
| colony stimulating factor 1a/b (csf1a/b)/macrophage colony stimulating factor (mcsf1/2) | Unconfirmed | csf1a (ENU screen); csf1b (Viral insertion) | (Wang et al., 2008) |
| colony stimulating factor 3 (csf3)/granulocyte colony stimulating factor (gcsf) | Unconfirmed | ENU screen | (Liongue et al., 2009) |
| csfr1a/cfms | panther | ENU screen | (Parichy et al., 2000) |
| dhx8 | mummy (mmy) | ENU screen | (English et al., 2012) |
| divalent metal transporter 1 (dmt1)/slc11a2 | chardonnay (cdy) | ENU screen | (Donovan et al., 2002) |
| epb41b/band4.1 | chablis (cha)/merlot (mot) | ENU screen | (Shafizadeh et al., 2002) |
| ephrin b2a | Unconfirmed | ENU screen | (Lawson et al., 2001) |
| ets variant gene 2 (etv2) | ENU screen | (Pham et al., 2007) | |
| ferrochetalase (fech) | frx/dracula (drc) | ENU screen | (Childs et al., 2000) |
| ferroportin1 (fpn1) | weissherbst (weh) | ENU screen | (Donovan et al., 2000) |
| fibrinogen, alpha chain (fga) | Unconfirmed | ENU screen | (Vo et al., 2013) |
| fli1a | (Liu and Patient, 2008) | ||
| flt4 | expando | ENU screen | (Hogan et al., 2009) |
| gata1a | vlad tepes (vld) | ENU screen TILLING |
(Lyons et al., 2002) |
| gata2a | Zinc-finger nuclease | (Zhu et al., 2011) | |
| globin (locus control region) | zinfandel (zin) | ENU screen | (Brownlie et al., 2003) |
| glutaredoxin 5 (grx5) | shiraz (shz) | ENU screen | (Wingert et al., 2005) |
| hairy/enhancer of split related with YRPW motif 2 (hey2) | gridlock (grl) | ENU Screen | (Zhong, 2000) |
| histone deacetylase 1 (hdac1) | ascending and descending (add)/colgate (col) | ENU Screen; retroviral insertion | (Nambiar et al., 2007; Yamaguchi et al., 2005) |
| IGM | Unconfirmed | Retroviral | (Danilova et al., 2005) |
| ikaros (ikzf1) | ENU screen | (Schorpp et al., 2006) | |
| integrin, alpha 2b (itga2b/CD41) | Unconfirmed | ENU Mutagenesis | (Ma et al., 2011) |
| kdrl/fetal liver kinase 1 (flk1)/VEGF receptor 2 (VEGFR2) | ENU screen | (Covassin et al., 2006) | |
| LIM domain only 2 (lmo2) | ENU screen (targeted) | (Weiss et al., 2012) | |
| lymphocyte specific protein tyrosine kinase (lck) | Unconfirmed | ENU Mutagenesis | (Murayama et al., 2006) |
| mindbomb | mindbomb (mib); white tail (wit) | ENU screen | (Itoh et al., 2003) |
| mitoferrrin/slc25a37 | frascati (frs) | ENU screen | (Shaw et al., 2006) |
| myeloid differentiation primary response gene 88 (myd88) | TILLING | (van der Vaart et al., 2013) | |
| myeloperoxidase (mpx/mpo) | durif (drf) | ENU screen | (Pase et al., 2012) |
| phospholipase C, gamma 1 (plcγ1) | deadbeat (ded) | 2004: retroviral insertion; 2005 and 2009: ENU screen | (Amsterdam et al., 2004; Covassin et al., 2009; Rottbauer et al., 2005) |
| protoporphyrinogen oxidase (ppox) | montalcino (mno) | ENU screen | (Dooley et al., 2008) |
| pu.1/spi1b | TILLING | (Jin et al., 2012) | |
| recombination activating gene 1 (rag1) | TILLING | (Wienholds et al., 2002) | |
| ribosomal protein L11 (rpl11) | Retroviral Insertion | (Danilova et al., 2011) | |
| runt-related transcription factor 1 (runx1) | TILLING | (Sood et al., 2010) | |
| slc4a1a/band3 | retsina (ret) | ENU screen | (Paw et al., 2003) |
| sonic hedgehog (shha) | sonic you (syu) | ENU Screen | (Schauerte et al., 1998) |
| squamous cell carcinoma antigen recognized by T-cells 3 (sart3) | earl grey (egy) | ENU-EP screen (targeted: T-cells); | (Trede et al., 2007) |
| T-box gene 16 (tbx16) | spadetail (spt) | ENU screen | (Griffin et al., 1998) |
| T-Cell acute lymphocytic leukemia 1 (tal1)/stem cell leukemia (scl) | ENU screen (targeted: vessels) | (Bussmann et al., 2007) | |
| TEK tyrosine kinase, endothelial (tie2/tek) | TILLING | (Gjini et al., 2011) | |
| tif1γ | moonshine (mon) | ENU screen | (Ransom et al., 2004) |
| transcription factor cmyb (cmyb) | 2010: ENU screen (targeted: T-cells); 2011: ENU screen | (Soza-Ried et al., 2010; Zhang et al., 2011) | |
| transducin (beta)-like 3 (tbl3) | ceylon (cey) | ENU-EP screen (targeted: T-cells) | (Hutchinson et al., 2012; Trede et al., 2008) |
| transferrin1 (tfr1) | chianti (cia) | ENU screen | (Wingert et al., 2004) |
| uroporphyrinogen decarboxylase (urod) | yquem (yqe) | ENU screen | (Wang et al., 1998) |
| v-ets erthroblastosis virus E26 oncogene homolog 2 (ets2) | Unconfirmed | Retroviral Insertion | (Liu and Patient, 2008) |
| Vascular Endothelial Growth Factor (VEGF) | (Lawson et al., 2002) | ||
| Von Hippel-Lindau (vhl) | TILLING | (van Rooijen et al., 2009) | |
| β-spectrin | riesling (ris) | ENU screen | (Liao et al., 2000) |
| δ-aminolevulinate synthase 2 (alas2) | sauternes (sau) | ENU screen | (Brownlie et al., 1998) |
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